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Shivhare, U. D.
- formulation of Povidone Iodine Vaginal Suppository Containing Lacto Bacillus Spores.
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Authors
Affiliations
1 MJRP college of heath Care and Allied Sciences, MJRP university, Jaipur, IN
1 MJRP college of heath Care and Allied Sciences, MJRP university, Jaipur, IN
Source
Asian Journal of Pharmaceutical Research, Vol 3, No 1 (2013), Pagination: 6-9Abstract
Human vagina represents a dynamic ecosystem dominated by certain species of Lactobacillus. This microorganism restricts the growth of pathogens by using properties of steric exclusion and inhibitory substance production. Serious complications including bacterial vaginosis and vaginal cancer are often determined in women with reduced numbers of lactobacilli. Local application of Lactobacillus is consequently promising to keep the vagina colonized by this strain, which consequently reduces the infections. The first objective of this research was to develop a local application pharmaceutical formulation of a vaginal suppository containing lyophilized culture of Lactobacillus with anti microbial agent Povidone iodine. The second objective was to establish a stable clindamycine suppositiry alone with Lactic acid Bacillus Spores for vaginosis.Keywords
Vaginosis, Lactic Acid Bacillus Spores, Povidone Iodine, Formulation, Viability, Stability
References
- Penn RL. Gynecological and obstetrical infections. In: Reese RE, Gordon Douglas Jr. R, 2nd ed. A practical approach to infectious diseases. Boston: Little, Brown and Company; 1986. p.385-421.
- Thadepalli H, Gorbach SL, Keith L. Anaerobic infections of the female genital tract; bacteriologic and therapeutic aspects. Am-J Obstet Gynecol 1973;117:1034-40.
- Ledger WJ. Micro-organisms that cause infection. In: Ledger WJ, ed. Infections in the female. 2nd ed. Philadelphia: Lea & Febiger;1986.p.9-34.
- Ledger WJ. Antimicrobial agents. In: Ledger WJ,2nd ed. Infections in the female. Philadelphia: Lea & Febiger;1986.p.95- 126.
- Bleker OP, Folkertsma K, Dirks-Go SIS. Diagnostic procedures in vaginitis. Eur J Obstet Gynecol Reprod Biol 1989;31:10-11.
- Bleker OP, Folkertsma K, Dirks-Go SIS. Diagnostic procedures in vaginitis. Eur J Obstet Gynecol Reprod Biol 1989;31:179-83.
- McFarland LV. Beneficial microbes: health or hazard? Eur J Gastroenterol Hepatol 2000;12:1069-1071.
- Gionchetti P, Rizzello F, Venturi A, Campieri M. Probiotics in infective diarrhoea and inflammatory bowel diseases. J Gastroenterol Hepatol 2000;15:489-493.
- Larsen B. Vaginal flora in health and disease. Clin Obstet Gynecol 1993;36:107-121.
- Redondo-Lopez V, Cook RL, Sobel JD. Emerging role of lactobacilli in the control and maintenance of the vaginal bacterial microflora. Rev Infect Dis 1990; 12:856-872.
- Hiller SL. The vaginal microbial ecosystem and resistance to HIV. AIDS Res Hum Retroviruses 1998;14(suppl 1):17-21.
- Boris S, Barbes C. Role played by lactobacilli in controlling the population of vaginal pathogens. Microbes Infect 2000;2:543- 546.
- Sobel JD. Vaginitis. N Engl J Med 1997;337:1896-1903.
- McGregor JA, French JI. Bacterial vaginosis in pregnancy. Obstet Gynecol Surv 2000;55(suppl 5):1-19.
- Sweet RL. Role of bacterial vaginosis in pelvic inflammatory diseases. J Infect Dis 1995; 20(suppl 2):271-275.
- Sooper DE. Bacterial vaginosis and postoperative infections. Am J Obstet Gynecol 1993; 169:467-469.
- Van de Wijgert, J.H.H.M., Mason, P.R. and Gwanzura, L. et al. Intravaginal practices, vaginal £ora disturbances, and acquisition of sexually transmitted diseases in Zimbabwean women. J. Infect. Dis. 2000;181,587-594.
- Chaim, W., Mazor, M. and Leiberman, J.R. (1997) The relationship between bacterial vaginosis and preterm birth. Arch. Gynecol. Obstet.1997;259:51-58.
- Reid G. and Bruce, A.W. Selection of Lactobacillus strains for urogenital probiotic applications. J. Infect. Dis. 2001;183(Suppl.1);77-80.
- Reid, G., Bruce, A.W. and Taylor, M. Instillation of Lactobacillus and stimulation of indigenous organisms to prevent recurrence of urinary tract infections. Microecol Ther.1995; 23: 32-45.
- Adham I S, Gilbert P. Effect of polyvinylpyrrolidone molecular weight upon the antimicrobial activity of povidoneiodine antiseptics. Int. J. Pharm.1986;34:45-49.
- Valenta C, Kast C E, Harich I, Bernkop-Schnurch A. Development and in vitro evaluation of a mucoadhesive vaginal delivery system for progesterone. J. Controlled Release 2001; 77: 323-332.
- Rodeheaver G, Bellamy W, Kody M, Spatafora G, Fittor L, Leyden K, Edlich R.,Bactericidal Activity And Toxicity of Iodine-Containg Solutions In Wounds Arch.Surg.1982;117:181- 186.
- Robson M C, Schaerf R.H.M, Kriek T.J, “Evaluation of Topical Povidone- Iodine Ointmenat in Experimental Burn Wound Sepsis” Plastic Reconstr. Surg. 1974;54:328-334.
- Sanae K, and Nattha K, Formulation and Evaluation of Vaginal Suppositories Containing Lactobacillus, World Academy of Science, Engineering and Technology 2009;(31):630-633.
- Formulation development and release studies of indomethacin suppositories, ML sah, TR Saini, short communications, Ind. J. pharm. Sciences 2008;70(4):498-501.
- Naikwade Sonali R, Kulkarni Pratibha P, Jathar Shripad R, Bajaj Amrita N. DARU 2008; 16 (3):119-127.
- Formulation of Clotrimazole Vaginal Suppository Containing Lacto bacillus Spores
Abstract Views :398 |
PDF Views:2
Authors
Affiliations
1 MJRP college of heath Care and Allied Sciences, MJRP university, Jaipur, IN
2 Sharad Pawar College of Pharmacy, Nagpur, IN
1 MJRP college of heath Care and Allied Sciences, MJRP university, Jaipur, IN
2 Sharad Pawar College of Pharmacy, Nagpur, IN
Source
Asian Journal of Pharmacy and Technology, Vol 3, No 1 (2013), Pagination: 5-8Abstract
Human vagina represents a dynamic ecosystem dominated by certain species of Lactobacillus. This microorganism restricts the growth of pathogens by using properties of steric exclusion and inhibitory substance production. Serious complications including bacterial vaginosis and vaginal cancer are often determined in women with reduced numbers of lactobacilli. Local application of Lactobacillus is consequently promising to keep the vagina colonized by this strain, which consequently reduces the infections. The first objective of this research was to develop a local application pharmaceutical formulation of a vaginal suppository containing lyophilized culture of Lactobacillus with anti microbial agent clotrimazole. The second objective was to establish a stable clotrimazole suppositiry alone with Lactic acid Bacillus Spores for vaginosis.Keywords
Vaginosis,Lactic acid bacillus Spores, Clotrimazole, Formulation, Viability, StabilityReferences
- Penn RL. Gynecological and obstetrical infections. In: Reese RE, Gordon Douglas Jr. R, 2nd ed. A practical approach to infectious diseases. Boston: Little, Brown and Company; 1986.p.385-421.
- Thadepalli H, Gorbach SL, Keith L. Anaerobic infections of the female genital tract; bacteriologic and therapeutic aspects. Am-J Obstet Gynecol 1973;117:1034-40.
- Ledger WJ. Micro-organisms that cause infection. In: Ledger WJ, ed. Infections in the female. 2nd ed. Philadelphia: Lea & Febiger;1986.p.9-34.
- Ledger WJ. Antimicrobial agents. In: Ledger WJ,2nd ed. Infections in the female. Philadelphia: Lea & Febiger;1986.p.95- 126.
- Bleker OP, Folkertsma K, Dirks-Go SIS. Diagnostic procedures in vaginitis. Eur J Obstet Gynecol Reprod Biol 1989;31:10-11.
- Bleker OP, Folkertsma K, Dirks-Go SIS. Diagnostic procedures in vaginitis. Eur J Obstet Gynecol Reprod Biol 1989;31:179-83.
- McFarland LV. Beneficial microbes: health or hazard? Eur J Gastroenterol Hepatol 2000;12:1069-1071.
- Gionchetti P, Rizzello F, Venturi A, Campieri M. Probiotics in infective diarrhoea and inflammatory bowel diseases. J Gastroenterol Hepatol 2000;15:489-493.
- Larsen B. Vaginal flora in health and disease. Clin Obstet Gynecol 1993; 36:107-121.
- Redondo-Lopez V, Cook RL, Sobel JD. Emerging role of lactobacilli in the control and maintenance of the vaginal bacterial microflora. Rev Infect Dis 1990; 12:856-872.
- Hiller SL. The vaginal microbial ecosystem and resistance to HIV. AIDS Res Hum Retroviruses 1998; 14(suppl 1):17-21.
- Boris S, Barbes C. Role played by lactobacilli in controlling the population of vaginal pathogens. Microbes Infect 2000;2:543- 546.
- Sobel JD. Vaginitis. N Engl J Med 1997; 337:1896-1903. 14. McGregor JA, French JI. Bacterial vaginosis in pregnancy. Obstet Gynecol Surv 2000;55(suppl 5):1-19.
- Sweet RL. Role of bacterial vaginosis in pelvic inflammatory diseases. J Infect Dis 1995; 20(suppl 2):271-275.
- Sooper DE. Bacterial vaginosis and postoperative infections. Am J Obstet Gynecol 1993; 169:467-469.
- Van de Wijgert, J.H.H.M, Mason P.R, Gwanzura L. Intravaginal practices, vaginal £ora disturbances, and acquisition of sexually transmitted diseases in Zimbabwean women. J. Infect. Dis. 2000;181,587-594.
- Chaim W, Mazor M, Leiberman J.R.The relationship between bacterial vaginosis and preterm birth. Arch. Gynecol. Obstet.1997;259: 51-58.
- 19.Reid G. and Bruce, A.W. Selection of Lactobacillus strains for urogenital probiotic applications. J. Infect. Dis. 2001;183 (Suppl.1),77-80.
- Reid G, Bruce, A.W. and Taylor, M. Instillation of Lactobacillus and stimulation of indigenous organisms to prevent recurrence of urinary tract infections. Microecol Ther 1995;23:32-45.
- Ritter. W. Pharmacokinetic fundamentals of vaginal treatment with clotrimazole. Am J Obstet Gynecol 1985;152:5-7.
- Gachotte D, Pierson CA, Lees ND, Barbuch R, Koegel C, Bard M. A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme. Proc Natl Acad Sci U S A. 1997; 94(21):11173-8
- Pastorek JG, CotchMF, Martin DH, Eschenbach DA. Vaginal Infections and Prematurity Study Group: clinical and microbiological correlates of vaginal trichomoniasis during pregnancy. Clin Infect Dis 1996;23:1075-80.
- Warrilow AG, Martel CM, Parker JE, Melo N, Lamb DC, Nes WD, Kelly DE, Kelly SL. Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51). Antimicrob Agents Chemother. Epub 2010 Oct;54(10):4235-45.
- Sorvillo F, Kerndt P. Trichomonas vaginalis and amplifications of HIV- 1 transmission. Lancet 1998; 351(9097):213-4.
- Sanae K, and Nattha K, Formulation and Evaluation of Vaginal Suppositories Containing Lactobacillus, World Academy of Science, Engineering and Technology 2009;(31):630-633
- Formulation development and release studies of indomethacin suppositories, ML sah, TR Saini, short communications, Ind. J. pharm. Sciences 2008;70(4):498-501.
- Naikwade Sonali R, Kulkarni Pratibha P, Jathar Shripad R, Bajaj Amrita N. DARU 2008;16(3):119-127.
- Contribution of Traditional Medicines to the Development of Modern Medicine for Malaria
Abstract Views :223 |
PDF Views:2
Authors
Affiliations
1 Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur- 441 110 (M.S.), IN
1 Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur- 441 110 (M.S.), IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 1 (2011), Pagination: 1-4Abstract
Malaria is caused by protozoan parasites of the genus Plasmodium. The most serious forms of the disease are caused by Plasmodium falciparum and Plasmodium vivax, but other related species (Plasmodium ovale, Plasmodium malariae) can also affect humans. The initial symptoms of malaria which include fever, headache and muscular aches. Plasmodium develops in the gut of the mosquito and passed in the saliva of an infected insect each time it takes a new blood meal. The parasites are then carried by the blood in the victim's liver where they invade the cells and multiply. After 9-16 days they return to the blood and penetrate the red cells, where they multiply again, progressively breaking down the red cells. In cerebral malaria, the infected red cells obstruct the blood vessels in the brain. The four species of malaria are distinguished by their different appearances of Trophozoites, Schizonts, Gametocytes and staining, size and shape of infected red blood cells, and other characteristics. The key role of traditional medicine in the development of modern medicine for prevention of malaria is discussed in this article. In-vitro and in-vivo antiplasmodial activities are experimental models for detecting antiplasmodial activity of plant extracts in the erythrocytic stage of malaria parasites. The study is likely to promote a rational use of botanicals and must be continued focusing on the isolation and characterizing active principles of the crude extract, its pharmacological validation, standardization and formulation.Keywords
Malaria, Plasmodium falciparum, Antiplasmodial Activity.References
- Cox F. History of human parasitology. Clinical Microbiol Rev. 2002; 15 (4): 595-612.
- Breman J. The ears of hippopotamus: manifestations, determinants and estimates of the malarial burden. Am J Trop Med Hyg. 2001; 64 (1-2): 1-11.
- Greenword BM, Bojang K, Whitty CJ and Targett GA. Malaria. Lancet. 2005; 365: 1487-1498.
- Van Benthem B, Vanwambeke S, Khantikul N, Burghoorn-Mass C, Panart K, Oskam L, Lambin E and Samboon P. Spatial patterns of and risk factors for seropositivity for dengue infection. Am J Trop Med Hyg. 2005; 72(2): 201-208.
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- Foley M and Tilley L. Quinoline antimalarials: Mechanism of action and resistance and prospects for new agents. Pharmacol Ther. 1998; 79: 55-87.
- http://www.textbooksonline.tn.nic.in
- http://www.malaria.org.za
- Tinto H, Rwagacondo C and Karema C. In-vitro suceptibility of Plasmodium falciparum to monodesethylamodiaquine, dihydroartemisin and quinine in an area of high chloroquine esistance in Rwand. Trans R Soc Trop Med Hyg. 100 (6): 509-514.
- Ridley RG. Medical need, scientific opportunity and drive for antimalarial drugs. Nature. 2002; 415: 686-693.
- Ronn AM, Msangeni HA, Mhina J, Wernsdorfer WH and Bygbjerg IC. High level of resistance of P. falciparum to sulfadoxime-pyrimethamine in children in Tanzania. Trans R Soc Trop Med Hyg. 1996; 90: 179-181.
- Sowunmi A, Oduola AM, Ogundahunsi OA and Salako LA. Comparitive efficacy of chlroquine plus chlorophenaramine and pyrimethamina/sulfadoxine in acute uncomplicated falciparum malaria in Nigerian children. Trans R Soc Trop Med Hyg. 1998; 92: 77-81.
- White NJ. Drug resistance in malaria. Br Med Bull. 1998. 54: 703-715.
- Foote SJ and Cowman AF. The mode of action and the mechanism of resistance to antimalarial drugs. Acta Trop. 1994; 56: 157-171.
- Ward SA, Bray BG, Mungthin M and Hawley SR. Current views on the mechanism of resistance to quinoline containing drugs in P. falciparum. Ann Trop Med Parasitol. 1995; 89: 121-124.
- Chawira AN and Warhurst DC. The effect of Artemisinin combined with standard antimalarils against chloroquine sensitive and chloroquine resistant strains of P. falciparum invitro. J Trop med Hyg. 1987; 90: 1-8.
- Olliaro PL and Trigg PI. Status of antimalarial drugs under development. Bull World Health Organ. 1995; 73: 565-571.
- Willcox M and Bodeker G. An Overview of Ethnobotonical Studies on Plants Used for the treatment of Malaria. In Merlin Willcox, Gerard Bodeker and Philippe Rasoanaivo's. Traditional medicinal Plants and Malaria. CRC Press, London.
- Evaluation of Anti-inflammatory Potential of Cyathocline lyrata Cass Plant Extract by Using Carrageenan Induced and Formalin Induced Rat Paw Edema
Abstract Views :215 |
PDF Views:4
Authors
Affiliations
1 MJRP College of Heath Care and Allied Sciences, MJRP University, Jaipur, IN
2 Sharad Pawar College of Pharmacy, Nagpur, IN
1 MJRP College of Heath Care and Allied Sciences, MJRP University, Jaipur, IN
2 Sharad Pawar College of Pharmacy, Nagpur, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 3, No 2 (2013), Pagination: 90-94Abstract
The present study was aimed at evaluating the chloroform extracts of whole part of Cyathocline lyrata cass antiinflammatory activity. Anti-inflammatory activity of chloroform extracts of whole part of Cyathocline lyrata cass was evaluated by carrageenan induced hind paw edema and Formalin induced paw edema method. Chloroform extracts of whole part of Cyathocline lyrata cass produced significant Anti-inflammatory activity when evaluated by carrageenan induced hind paw edema and Formalin induced paw edema method respectively. The interpretation of the results was done after subjecting the data obtained from various studies to statistical analysis which included one-way ANOVA followed by post-hoc with Dunnets t-test. The results suggest that the chloroform extracts of whole part of Cyathocline lyrata cass posses anti-inflammatory.Keywords
Cyathocline lyrata cass, Anti-inflammatory, Carrageenan Induced Hind Paw Edema, Formalin Paw Edema.References
- Shrivastava R, Anthelmintic properties of essential oil of Cyathocline lyrata Cass., Indian journal of Pharmaceutical Sciences 1979;41:228-229.
- Tripathi KD. Essentials of Medical Pharmacology. 5th Edn, Jaypee Brothers Medical Publishers (P) Ltd.; 2003,p.453
- Rang HP, Dale MM, Ritter JM, Moore PK. Pharmacology. 5th Edn, Elservier; 2006,p. 246.
- Sosa S, Balicet MJ, Arvigo R, Esposito RG, Pizza C, Altinier GA. Screening of the topical anti-inflammatory activity of some central American plants. J Ethanopharmacol 2002; 8:211–215.
- Michel YB, Dubois, Christopher G, Allen HL. Chronic pain management. In: Healy TEJ, Knight PR, eds. Wylie and Churchil-Davidson’s A practice of Anaesthesia .7th edition. London, 2003, p.1235–1139.
- Pilotto A, Franceschi M, Leandro G. The risk of upper gastrointestinal bleeding in elderly users of aspirin and other nonsteroidal anti-inflammatory drugs: the role of gastroprotective drugs. Aging Clin Exp Res 2003; 15(6):494–499.
- kokon JE, Nwafor P, 2010. Antiinflammatory, analgesic, and antipyretic activities of ethanolic ischolar_main extract of Croton zambesicus. Pakistan Journal of Pharmaceutical Sciences, 23: 385-392.
- Roy A, Gupta JK, Lahiri SC. 1982. Further studies on antiinflammatory activity of two potent indan-1-acetic acids. Indian J. Physiol. Pharmacol, 26: 206-214.
- Formulation of Tinidazole Vaginal Suppository Containing Lacto Bacillus Spores
Abstract Views :186 |
PDF Views:0
Authors
Affiliations
1 Sadar Bazar B/H Ram Mandir At Post Paratwada, Dist- Amravati (M.S) Pin code- 444805, IN
2 Sharad Pawar College of Pharmacy, Nagpur, IN
3 MJRP College of Heath Care and Allied Sciences, MJRP University, Jaipur, IN
1 Sadar Bazar B/H Ram Mandir At Post Paratwada, Dist- Amravati (M.S) Pin code- 444805, IN
2 Sharad Pawar College of Pharmacy, Nagpur, IN
3 MJRP College of Heath Care and Allied Sciences, MJRP University, Jaipur, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 5, No 2 (2013), Pagination: 75-78Abstract
Human vagina represents a dynamic ecosystem dominated by certain species of Lactobacillus. This microorganism restricts the growth of pathogens by using properties of steric exclusion and inhibitory substance production. Serious complications including bacterial vaginosis and vaginal cancer are often determined in women with reduced numbers of lactobacilli. Local application of Lactobacillus is consequently promising to keep the vagina colonized by this strain, which consequently reduces the infections. The first objective of this research was to develop a local application pharmaceutical formulation of a vaginal suppository containing lyophilized culture of Lactobacillus with anti microbial agent tinidazole. The second objective was to establish a stable tinidazole suppositiry alone with Lactic acid Bacillus Spores for vaginosis.Keywords
Vaginosis, Lactic Acid Bacillus Spores, Tinidazole, Formulation, Viability, Stability Test.- A Review: Indian Pharmaceutical Education and its Regulatory Authorities
Abstract Views :257 |
PDF Views:0
Authors
Affiliations
1 MJRP College of Heath Care and Allied Sciences, MJRP University, Jaipur, IN
2 Sharad Pawar College of Pharmacy, Nagpur, IN
3 BM College of Pharmaceutical Education and Research, Indore (M.P), IN
1 MJRP College of Heath Care and Allied Sciences, MJRP University, Jaipur, IN
2 Sharad Pawar College of Pharmacy, Nagpur, IN
3 BM College of Pharmaceutical Education and Research, Indore (M.P), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 1 (2012), Pagination: 14-18Abstract
The present article aimed at focusing the different courses being conducted to prepare the manpower for the pharmacy profession i.e. each and every field which is directly or indirectly related to the production and sell of drugs. The article also highlights the regulatory bodies involved in designing the syllabus also the content of course at every stage of the course, the practical training that a student should undergo at every level. The brief discussion has been made about the functions of the regulatory bodies. A correlation has been made between the theoretical and practical content of the course with the present professional opportunities and the requirement of the Pharma industries. A little attempt has been made and some views are put through this platform for upgrading the standard of education to bridge the gape between the theoretical approach of the course and present need of the pharmacy profession at the industrial as well as educational level. Pharmacy education in India traditionally has been industry and product oriented. The information presented in this paper may stimulate discussion and critical analysis and planning, and will be of value in further adaptation of the pharmacy education to desired educational outcomes.Keywords
Pharmacy Education, Regulatory Bodies, PCI, AICTE, India.- Effect of Combination of Hydrophilic and Hydrophobic Polymers on Transdermal Drug Delivery Systems Properties
Abstract Views :185 |
PDF Views:0
Authors
Affiliations
1 Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur - 441 110, IN
1 Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur - 441 110, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 3, No 5 (2011), Pagination: 203-209Abstract
The matrix-type controlled transdermal drug delivery systems were prepared by solvent evaporation method using methanol: dichloromethane (1:1) as solvent for HPMC and ethanol as solvent for Eudragit RL 100 and Eudragit RS 100 (ERL 100 and ERS 100). In the evaluation tests it was found that formulation batch L1 (96.40%) was having more release as compared to formulation L2 (95.52%) but later had much better physicochemical properties and shown cumulative percentage diffusion 96.60% in 24 h. The transdermal patches were evaluated for their In vitro dissolution test and in vitro diffusion test, skin irritation test. Scanning electron microscopy was performed to characterize the transdermal patch.
Keywords
HPMC E15, Atenolol, Solvent Evaporation Method, Transdermal Patch, Dimethyl Sulphoxide.- Study of Antimicrobial Activity of Canarium strictum Gum Resin
Abstract Views :162 |
PDF Views:0
Authors
Affiliations
1 Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur- 441100 (M. S.), IN
1 Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur- 441100 (M. S.), IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 6 (2010), Pagination: 435-437Abstract
Canarium strictum Roxb. (Burseraceae) is used in the traditional Ayurvedic medicine under the name Raladhupa and black dammar resin. The isolation of compound A and compound B were carried out from chloroform extract by counter current distribution method. The purity of each compound was estimated by using Thin Layer Chromatography. The preliminary phytochemical screening of each compounds showed the presence of triterpenoid. The compound A and Compound B were investigated for antimicrobial (antibacterial and antifungal) activity by using cup plate method or diffusion agar method. The results obtained shows that compound A and compound B possess broad-spectrum antimicrobial activity at concentration of 100μg/ml. The inhibitory effect of each compound is very close and identical in magnitude for Gram- positive, Gram-negative bacteria and fungi.Keywords
Canarium Strictum, Raladhupa, Black Dammar Resin, Antimicrobial Activity.- Evaluation of Analgesic Potential of Cyathocline lyrata cass Plant in Rats by Using Tail Flick and Hot Plate Method
Abstract Views :174 |
PDF Views:1
Authors
Affiliations
1 MJRP College of Heath Care and Allied Sciences, MJRP University, Jaipur, IN
2 Sharad Pawar College of Pharmacy, Nagpur, IN
1 MJRP College of Heath Care and Allied Sciences, MJRP University, Jaipur, IN
2 Sharad Pawar College of Pharmacy, Nagpur, IN